Attapulgite in the treatment of acute diarrhoea: a double- ...

06 Aug.,2024

 

Attapulgite in the treatment of acute diarrhoea: a double- ...

A double-blind placebo-controlled study was carried out to assess the therapeutic effects of Attapulgite, a purified hydrated aluminium magnesium silicate, as an additional agent to oral rehydration solutions in 30 adults with mild-to-moderate acute diarrhoea where no bacterial or protozoal causes could be identified. The study subjects were give 600 mg tablets of Attapulgite or placebo in a random order and followed up for 72 hours. Attapulgite was observed to be significantly better than placebo in reducing the severity and duration of diarrhoea in terms of frequency of motion and consistency of stools (p < 0.01), severity of dehydration (p < 0.01) and in reducing the amount of ORS consumed (p < 0.05). Attapulgite was also well-tolerated. Attapulgite, therefore, merits attention as an additional safe agent besides ORS for the treatment of mild-to-moderate acute diarrhoea.

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attapulgite | Actions and Spectrum

Actions and Spectrum: 

attapulgite is a type of clay mineral widely used in various industries for its unique properties. Its primary application is as an absorbent and anti-caking agent, but it is also used as a binder, thickener, and rheological modifier in various products. 

The action of attapulgite is primarily physical. When added to a liquid, it forms a network of interlocking particles that trap and hold onto other particles, such as dirt, oil, and other impurities. This action makes attapulgite an effective adsorbent and clarifying agent in many industrial processes. 

The spectrum of attapulgite refers to its range of applications and the properties that make it suitable for different uses. attapulgite has many applications in agriculture, pharmaceuticals, cosmetics, and oil drilling industries. It is also used as catalyst support in chemical reactions and as a carrier for active ingredients in drug formulations. 

DRUG INTERACTION

attapulgite

&

  • naloxone intranasal
  • clomiphene
  • patisiran
  • imetelstat
  • phenylephrine ophthalmic
  • myoinositol
  • vasicinone
  • soda lime
  • fisetin
  • Reynoutria Japonica
  • Coco Monoethanolamide
  • Betadex
  • lithopone
  • cyperus rotundus
  • papaya juice
  • 1-naphthaleneacetic acid
  • Nordazepam
  • Glechoma hederacea
  • Alternanthera sessilis
  • nicofetamide
  • napthol asol
  • cocamidopropyl betaine
  • musa x paradisiaca
  • dicyclomine/mefenamic acid
  • Sorghum
  • Manganese citrate
  • tovorafenib
  • mefenamic acid/paracetamol
  • eschscholzia californica
  • canna indica root
  • tranexamic acid/mefenamic acid
  • dexverapamil
  • sitogluside
  • secalciferol
  • cefatrizine
  • Sedum Acre
  • Flurogestone
  • Fluocortin
  • Bifendate
  • piprozolin
  • aminacrine undecylate
  • ethylenediamine mandelate
  • pelubiprofen
  • hesperetin
  • butethamine
  • epitiostanol
  • androstenediol
  • Nitroxoline
  • Iocarmic acid
  • Capobenic acid
  • dordaviprone (investigational drug)
  • Vitexin
  • Friluglanstat (investigational drug)
  • scorias spongiosa
  • Luseogliflozin
  • indoxacarb
  • prademagene zamikeracel
  • fidanacogene elaparvovec-dzkt
  • albifylline
  • idanpramine
  • araneus diadematus
  • Sulfamazone
  • Lycosa tarantula
  • malotilate
  • Ethacizine
  • Namilumab
  • Latrunculin B
  • stachyose
  • platinic oxide
  • iopronic acid
  • calcium chloride / potassium chloride/lactic acid/ sodium chloride/sodium hydroxide/sodium lactate solution
  • citric acid/ sodium bicarbonate/ sodium carbonate anhydrous
  • vadadustat
  • permethrin medical grade cis/trans isomers 25/75
  • lutetium, isotope of mass 177
  • human normal immunoglobulin
  • sacrosidase
  • apadamtase alfa, recombinant
  • acetyl hexapeptide-8 amide
  • pemivibart (Investigational)
  • govorestat
  • Zanidatamab
  • sotat&#;rc&#;pt
  • MV 140 vaccine
  • leuprorelin implant
  • cinchocaine hydrochloride/fluocortolone hexanoate/fluocortolone pivalate
  • Beautyberry
  • risedronate/calcium/vitamin D3
  • rhubarb extract/senna leaf/sulphur purified/wood charcoal
  • boric acid/kaolin/methyl salicylate/peppermint oil/thymol
  • docosahexaenoic acid/eicospentaenoic acid
  • aluminium hydroxide/magnesium hydroxide/simethicone
  • gentamicin/hydrocortisone
  • succinylcholine
  • sinefungin
  • letibotulinumtoxinA
  • coal tar/coconut oil/salicylic acid
  • camphor/camphor oil white/capsicum oleoresin /menthol/methyl salicylate
  • thioglycolic acid
  • acetic acid auricular
  • roluperidone
  • hydrocortisone/crotamiton topical
  • nystatin/chlorhexidine
  • aluminium chloride hexahydrate
  • ketoprofen topical
  • Chlormethine
  • podophyllotoxin
  • urea/lactic acid
  • autologous chondrocytes implant
  • afelimomab
  • gepotidacin
  • fludroxycortide
  • fentanyl transdermal
  • erythromycin/zinc acetate
  • dibotermin alfa powder
  • desferrioxamine mesilate
  • choline salicylate/magnesium salicylate
  • castor oil/peru balsam/trypsin
  • betamethasone/dexchlorpheniramine maleate
  • benzalkonium chloride solution/cetrimide
  • barzolvolimab
  • ascorbic acid / calcium laevulinate / nicotinamide / calcium pantothenate / calcium chloride / riboflavine / pyridoxine hydrochloride / thiamine hydrochloride
  • argipressin
  • arachis oil refined/chlorobutanol hemihydrate
  • arachis oil/eucalyptol/nutmeg oil/terpineol
  • ammonium chloride/diphenhydramine hydrochloride/levomenthol
  • amino acid mixture d / calcium chloride dihydrate / glucose monohydrate / glycine / magnesium chloride hexahydrate / olive oil / potassium chloride / sodium acetate trihydrate / sodium glycerophosphate pentahydrate / soya-bean oil
  • biotin/colecalciferol/copper (ii)sulfate dried/ cyanocobalamine/ dl-alpha tocopherol acetate/dibasic calcium phosphate anhydrous/folic acid/iron (ii)sulfate dried/ lecithin/ magnesium sulfate dried/ nicotinamide/ pyridoxine hydrochloride/ riboflavin
  • ampicillin sodium / cloxacillin sodium
  • undecylenic acid, undecylenate salts, zincundecate
  • omeprazole/sodium bicarbonate
  • efgartigimod alfa/hyaluronidase
  • xylometazoline/ipratropium
  • cefepime and enmetazobactam
  • isotonic sodium chloride
  • bee venom allergen injection
  • fentanyl intranasal
  • alglucosidase alfa
  • triprolidine/pseudoephedrine
  • pegademase bovine
  • castor oil and peru balsam
  • camphor/eucalyptus oil/menthol
  • oxyquinoline/sodium lauryl sulfate
  • somatorelin
  • menotrophin injection
  • menadiol
  • hylan g-f 20
  • cefepime and taniborbactum
  • water avens
  • camphor/menthol
  • acoramidis
  • elafibranor
  • arrowroot
  • miconazole nitrate/hydrocortisone
  • vildagliptin/metformin
  • dobesilic acid
  • aroxybutynin and atomoxetine
  • hygromycin
  • linvoseltamab
  • nemolizumab
  • aceprometazine
  • limaprost
  • oxazolam
  • trimegestone
  • teceleukin
  • beauty berry
  • dinotefuran
  • imiprothrin
  • transfluthrin
  • thymalfasin
  • technetium Tc 99m tilmanocept
  • glepaglutide
  • marstacimab
  • pixantrone
  • Andiroba
  • arabinoxylan
  • arenaria rubra
  • etripamil
  • jequirity
  • jiaogulan
  • dusquetide
  • rolipram
  • tradipitant
  • sinfungin
  • diclofenac/omeprazole
  • brinzolamide and timolol maleate
  • wormseed
  • wormwood
  • wood sorrel
  • carmellose sodium
  • ibandronic acid
  • cinnarizine and dimenhydrinate
  • ursodeoxycholic acid
  • rhubarb extract/salicylic acid
  • butamirate citrate
  • fumitory
  • taheebo
  • uva ursi
  • vervain
  • coleus
  • coltsfoot
  • crampbark
  • plantain
  • potassium nitrate and silver nitrate
  • gelsemium
  • gentian
  • glucomannan
  • walnut
  • meadowsweet
  • midomafetamine
  • pennyroyal
  • periwinkle
  • betony
  • bitter orange
  • bladderwrack
  • bloodroot
  • emu oil
  • garcinia
  • yellow dock
  • burdock
  • dehydroepiandrosterone
  • aucubin
  • jasmone
  • resacetophenone
  • ecamsule ditriethanolamine
  • feclobuzone
  • fenoprop triethanolamine
  • verdyl acetate
  • caffeic acid
  • cyclamen aldehyde
  • dicetyldimonium chloride
  • wogonin
  • impacarzine
  • laurylpyridinium chloride
  • stepronin
  • matrine
  • sakuranin
  • cannabichromene
  • sandalore
  • sabinene
  • oxypaeoniflora
  • ethylhexyl pelargonate
  • acrylonitrile
  • allyl alcohol
  • dipalmitoylethyl hydroxyethylmonium methosulfate
  • butidrine
  • clothiapine
  • propanediol dicaprylate
  • buchu
  • undecanol
  • enilconazole
  • xymenynic acid
  • angelica
  • nizubaglustat
  • resomelagon
  • ulecaciclib
  • apple cider vinegar
  • bacopa
  • barley grass
  • dandelion
  • deer velvet
  • dolomite
  • bugleweed
  • bupleurum
  • glyceryltrinitrate
  • pociredir
  • asnuciclib
  • actalycabtagene autoleucel
  • butantan&#;dengue vaccine
  • travoprost/timolol
  • furosemide/potassium chloride
  • amylamine
  • jaborandi
  • patritumab deruxtecan
  • jackfruit
  • sterculia
  • ascorbigen
  • ashitaba
  • androstenetrione
  • andrachne
  • cosibelimab
  • racecadotril
  • neomycin/chlorhexidine
  • octocog alfa
  • cetrimide
  • ispaghula husk
  • polyhexanide
  • octenidine
  • polygeline
  • heparinoid
  • jewelweed
  • boldo
  • anizatrectinib
  • alpinia
  • henbane
  • cynanchum vincetoxicum root and sulfur
  • boditrectinib
  • izumerogant
  • zavondemstat
  • abuta
  • fadogia agrestis
  • fly agaric mushroom
  • meptazinol
  • methoxyflurane
  • tramadol/dexketoprofen
  • betaine/polyhexanide
  • filgotinib
  • inosine acedoben dimepranol
  • alverine citrate
  • hyoscine butylbromide
  • senna+ ispaghula
  • cabbage palm
  • cajeput oil
  • calanus oil
  • calamint
  • canada balsam
  • carnosine
  • alverine citrate/simeticone
  • dihydroartemisinin/piperaquine
  • mebeverine/ispaghula
  • calcipotriol
  • tacalcitol
  • triethyl citrate/ethyl linoleate
  • sodium dilauramidoglutamide lysine
  • fazamorexant
  • avibactam tomilopil and ceftibuten
  • drostanolone
  • tigilanol tiglate
  • isorhynchophylline
  • rhynchophylline
  • crisugabalin
  • epigallocatechin gallate
  • clomocycline
  • corynoxeine
  • isocorynoxeine
  • Culmerciclib
  • Neladenoson
  • ambrein
  • hexylcaine
  • phensuximide
  • resencatinib (investigational)
  • rolusafine
  • pumecitinib
  • arhalofenic acid
  • berdazimer sodium
  • benzquinamide
  • clidinium
  • sulfametopyrazine
  • fulzerasib (Investigational Drug)
  • rovadicitinib (Investigational Drug)
  • Upleganan (Investigational Drug)
  • menthyl ethylamido oxalate
  • quaternium-90 montmorillonite
  • unecritinib (investigational drug)
  • etohexadiol
  • guaiol
  • proximadiol
  • verdinexor
  • sofnobrutinib
  • talbutal
  • ethoxzolamide
  • propiomazine
  • enprofylline
  • phenmetrazine
  • merigolix
  • pralurbactam
  • neracorvir
  • vonifimod
  • apaziquone hydroquinone
  • darizmetinib
  • zandelisib
  • xininurad
  • ritivixibat
  • amiselimod phosphate (investigational drug)
  • emzeltrectinib (investigational drug)
  • ficonalkib
  • cinalukast
  • ulobetasol
  • candoxatril
  • nitrofural
  • acetyldigitoxin
  • bentiromide
  • dextrothyroxine
  • chlorotrianisene
  • remikiren
  • pipobroman
  • vidarabine
  • immune globulin intravenous, human-stwk
  • spermine
  • serine
  • N-acetyl glucosamine
  • valine
  • adenine
  • asparagine
  • citrulline
  • adinazolam
  • interferon alfacon-1
  • interferon alfa-n1
  • felypressin
  • birch triterpenes
  • pyridoxal phosphate
  • technetium Tc-99m arcitumomab
  • beta-alanine
  • dihomo-gamma-linolenic acid
  • urea/hydrocortisone
  • R21/Matrix-M vaccine
  • povidone-iodine (ophthalmic)
  • pheniramine
  • hydrocortisone rectal
  • chloroxylenol/pramoxine/zinc acetate
  • chloroxylenol/pramoxine
  • dextrose/sucrose/vitamin C/zinc sulphate
  • furazolidone/metronidazole/dicyclomine
  • ergocalciferol (vitamin D2)
  • benoxaprofen (discontinued)
  • teicoplanin
  • carbomer
  • chromic chloride / iron (ii) chloride tetrahydrate / potassium iodide / manganese chloride / sodium fluoride / sodium selenite pentahydrate / sodium molybdate dihydrate / zinc chloride/ cupric chloride
  • bufylline
  • lidocaine/prilocaine
  • opium tincture, squill oxymel
  • dibrompropamidine
  • metronidazole/tetracycline/bismuth subsalicylate
  • agnus- castus
  • velaglucerase alfa
  • alendronic acid / colecalciferol
  • bimatoprost / timolol
  • efbemalenograstim alfa
  • dried ferrous sulfate/folic acid
  • dried ferrous sulfate / sodium ascorbate
  • nirogacestat
  • soya-bean oil, medium-chain triglycerides
  • demeclocycline hydrochloride and triamcinolone acetonide
  • fusidic acid / hydrocortisone acetate
  • macrogol
  • storax, benzoin
  • nomegestrol acetate/estradiol
  • flumetasone pivalate/ clioquinol
  • berdazimer topical (Pending FDA Approval)
  • buflomedil
  • butobarbital
  • andexanet alfa
  • methoxypolyethylene glycol-epoetin beta
  • viscum abietis
  • pramoxine vaginal
  • bupivacaine implant
  • cromolyn sodium, inhaled
  • pneumococcal vaccine 20-valent
  • bimatoprost ophthalmic implant
  • tick-borne encephalitis vaccine
  • chloroprocaine ophthalmic
  • travoprost intraocular implant (Pending FDA approval)
  • typhoid polysaccharide vaccine
  • sodium phosphate rectal
  • human papillomavirus vaccine, nonavalent
  • peanut immunotherapy epicutaneous (FDA approval pending)
  • cromolyn sodium, intranasal
  • red blood cells(Blood component)
  • oral mucoadhesive
  • clindamycin vaginal
  • whole blood (Blood Component)
  • fibrinogen/thrombin
  • levothyroxine/liothyronine
  • ipratropium intranasal
  • metronidazole vaginal
  • cyamemazine
  • brinase
  • reviparin
  • ulinastatin
  • saruplase
  • acepromazine
  • emylcamate
  • methionine
  • amino acids and electrolytes in dextrose with calcium
  • slippery elm
  • camostat
  • hemoglobin crosfumaril
  • moperone
  • chlormidazole
  • brilaroxazine
  • palopegteriparatide
  • diazepam buccal
  • benegrastim (pending for FDA approval)
  • COVID-19 vaccine, adjuvanted-Novavax
  • vestronidase alfa-vjbk
  • tebipenem (Pending FDA Approval)
  • tislelizumab (Pending FDA Approval)
  • zolbetuximab (Pending FDA Approval)
  • zoliflodacin (pending FDA approval)
  • zibotentan and dapagliflozin
  • fluorine F18 DCFPyL
  • debamestrocel
  • givinostat
  • amubarvimab and romlusevimab(Pending FDA Approval)
  • sabizabulin(Pending FDA approval)
  • fexapotide(Phase 3 Clinical trial)
  • diatrizoic acid
  • drotaverine
  • diethyl phthalate
  • enclomiphene
  • epalrestat
  • ethamsylate
  • flupirtine
  • imidurea
  • sodium glycolate
  • feracrylum
  • ethacridine
  • furazolidone/metronidazole
  • ozagrel hydrochloride
  • leptazol
  • l-glutamic acid /vitamin B complex
  • etizolam
  • etizolam/propranolol
  • ethoheptazine citrate
  • etophylline and theophylline
  • etophylline
  • finger millet
  • drotaverine/mefenamic acid
  • dichloroxylenol
  • pneumococcal 7-valent vaccine
  • diclofenac and metaxalone
  • dipivefrin ophthalmic
  • enbucrilate
  • potassium citrate and citric acid
  • potassium gluconate
  • aclarubicin
  • alfuzosin/dutasteride
  • adrenochrome monosemicarbazone
  • selenium sulfide topical
  • sertaconazole
  • amorolfine cream
  • amsacrine
  • amylmetacresol
  • sulfonated phenolics in aqueous solution
  • technetium Tc-99m sulfur colloid
  • raltitrexed
  • romiplostim
  • acediasulfone
  • azulene
  • acebrophylline
  • clonazepam/escitalopram oxalate
  • allylestrenol
  • andrographolide
  • artemotil
  • technetium Tc-99m sestamibi
  • rubidium Rb-82
  • somapacitan
  • sodium sulfate, magnesium sulfate and potassium sulfate
  • almitrine
  • gramicidin
  • nikethamide
  • technetium Tc-99m sodium pertechnetate
  • betiatide
  • prilocaine/epinephrine
  • amlexanox
  • acetaminophen/salicylamide/phenyltoloxamine
  • neomycin topical
  • zilucoplan
  • antazoline and xylometazoline
  • toripalimab
  • iron isomaltoside
  • meningococcal A C Y and W polysaccharide tetanus toxoid conjugate vaccine
  • meningococcal A C Y and W-135 diphtheria conjugate vaccine
  • tetradecyl Sulfuric Acid
  • benzoyl peroxide, clindamycin phosphate, adapalene
  • ethylephedrine
  • actarit
  • pyrantel tartrate
  • tenofovir disoproxil fumarate or tenofovir DF
  • melitracen
  • amitriptylinoxide(Phase 4 Clinical Trials)
  • threonine
  • ditiocarb zinc
  • epicriptine
  • levallorphan
  • kinetin
  • laurocapram
  • pentagastrin
  • parthenolide
  • nicoboxil
  • protionamide
  • prulifloxacin
  • proscillaridin
  • tizanidine and rofecoxib
  • tolnaftate, gentamicin, chinoform and betamethasone valerate
  • pine bark extract
  • pipenzolate methylbromide
  • bephenium hydroxynaphthoate
  • niclosamide
  • pyrvinium
  • pipenzolate methylbromide/phenobarbitone
  • piracetam/ginkgo biloba/vinpocetine
  • benzyl benzoate/disulfiram
  • benzyl benzoate
  • loperamide/simethicone
  • piroctone olamine
  • sodium fusidate
  • piroxicam topical/capsaicin/menthol/methyl salicylate
  • sodium metabisulfite
  • sodium lauryl sulfate
  • taspoglutide
  • glyclopyramide
  • tolnaftate, gentamicin, iodochlorohydroxyquinoline, chlorocresol, betamethasone valerate
  • serratiopeptidase
  • sodium antimony gluconate
  • triamterene / benzthiazide
  • tribenoside / lidocaine
  • triclocarban
  • triprolidine/dextromethorphan  
  • vitamins/minerals/omega-3 Fatty acids
  • soyabean oil
  • sucralfate/oxethazaine
  • sucralfate/tinidazole/povidone iodine
  • sodium cromoglycate
  • aloe vera/liquid paraffin/white soft paraffin
  • aloe vera/jojoba oil/vitamin E
  • allantoin/triclosan/vitamin e/zinc oxide
  • alpha-Lipoic acid/minerals/multivitamins
  • alprazolam/paracetamol
  • alprazolam/melatonin
  • azithromycin/ambroxol
  • atorvastatin/clopidogrel/aspirin
  • aceclofenac, paracetamol and serratiopeptidase
  • alfacalcidol, vitamin B-complex, minerals and antioxidants
  • alpha- lipoic acid, vitamin b complex and vitamin c
  • alpha-galactosidase and simethicone
  • alpha-galactosidase, amylase, proteases, lipase and lactase
  • amikacin and cefepime
  • aminophylline, ephedrine and phenobarbitone
  • artesunate, sulphadoxine and pyrimethamine
  • finasteride/tamsulosin
  • flavoxate/ofloxacin
  • fenofibrate/metformin
  • lignocaine, hydrocortisone topical and allantoin
  • linoleic acid and sodium lactate
  • troxerutin
  • meclizine/nicotinic acid
  • mecobalamin/ginkgo Biloba
  • spirulina
  • loperamide and furazolidone
  • ketoconazole/cetrimide
  • ketoconazole/zinc pyrithione
  • lercanidipine/atenolol
  • levocetirizine/montelukast/ambroxol
  • levarterenol
  • levocetirizine/phenylpropanolamine 
  • indapamide/amlodipine
  • itopride/methyl polysiloxane
  • mebendazole/levamisole
  • eberconazole/mometasone
  • gliclazide/metformin/pioglitazone
  • fluconazole/tinidazole
  • haemocoagulase
  • halometasone
  • hesperidin
  • imipramine/chlordiazepoxide
  • idebenone / l-arginine / zinc sulphate/selenium/proanthocyanidin
  • mecobalamin and piracetam
  • mesterolone
  • mosapride and pantoprazole
  • atorvastatin, co enzyme q10, vitamin e, zinc, and selenium
  • azithromycin and benzalkonium chloride
  • beta carotene, vitamin c, vitamin e, minerals, lutein, eicosapentaenoic acid, docosahexenoic acid and vit b12
  • alpha-galactosidase
  • aloe vera gel/vitamin e/lactic acid
  • aloe vera gel/jojoba/vitamin e/glycerine
  • famotidine and domperidone
  • faropenem medoxomil
  • nedosiran
  • fluconazole/ornidazole/azithromycin
  • ebastine/montelukast
  • eberconazole
  • dienogest/estradiol valerate
  • ambroxol/salbutamol
  • benzoic acid/salicylic acid/ichthammol/ triamcinolone acetonide
  • desloratadine/ambroxol
  • dexibuprofen/paracetamol
  • atorvastatin/ramipril
  • diastase
  • diastase and simethicone
  • diazepam and propranolol
  • dexrabeprazole / domperidone
  • dexrabeprazole
  • dexketoprofen /paracetamol
  • beta carotene/vitamin C/minerals
  • aloe vera gel/urea
  • aloe vera gel/glycerine
  • alpha-lipoic acid/benfotiamine/chromium/folic acid/mecobalamin / vit b6
  • alprazolam/propranolol
  • alprazolam /sertraline
  • ibuprofen/dextropropoxyphene
  • ambroxol/cetirizine/phenylephrine/ guaiphenesin/menthol
  • dextropropoxyphene/dexchlorpheniramine maleate/bromhexine
  • promegestone
  • batroxobin
  • bencyclane
  • benfluorex
  • acetylpheneturide
  • abarelix
  • abetimus
  • naftidrofuryl
  • nalorphine
  • oxiracetam
  • letosteine
  • lafutidine
  • leuprorelin
  • levodropropizine
  • glutaral
  • losartan/ramipril
  • gallopamil
  • lanatoside c
  • lauromacrogol
  • gestodene
  • aceclofenac/methyl salicylate/menthol/linseed oil/capsaicin
  • aceclofenac/paracetamol/tizanidine
  • alginic acid/magaldrate/simethicone
  • aceclofenac/paracetamol
  • aceclofenac/rabeprazole
  • alginic acid
  • pantoprazole and domperidone
  • urokinase
  • rimiterol
  • olanzapine/fluoxetine
  • normethadone/hydroxyephedrine
  • myrtol
  • moxonidine
  • propylhexedrine
  • sodium hypochlorite solution
  • sodium chloride/sodium citrate
  • Hepatitis B Vaccine (Recombinant [Adjuvanted])
  • Hepatitis B Vaccine (Recombinant)
  • aceclofenac and serratiopeptidase
  • levosulpiride
  • niaprazine
  • tromantadine
  • trimetazidine
  • vinburnine
  • mizoribine
  • molgramostim
  • mosapride
  • eugenol
  • tolperisone
  • etamsylate
  • etynodiol
  • mizolastine
  • metenolone
  • reproterol
  • rebamipide
  • mephenoxalone
  • metandienone
  • furosemide/spironolactone
  • hydroxycarbamide
  • tenonitrozole
  • fenoverine
  • fenquizone
  • tiapride
  • tibolone
  • furazolidone
  • furosemide & amiloride
  • fosfestrol
  • fluclorolone
  • flubendazole
  • tertatolol
  • tetracosactide
  • tetryzoline
  • tolciclate
  • trapidil
  • troxipide
  • temoporfin
  • telbivudine
  • teprenone
  • hexamidine
  • mebhydrolin
  • mepartricin
  • fencamfamin
  • medazepam
  • theodrenaline
  • thiamazole
  • thiocolchicoside
  • psilocybin
  • veralipride
  • pyritinol
  • opipramol
  • oprelvekin
  • betamethasone + gentamicin
  • betamethasone + neomycin
  • betamethasone + salicylic acid
  • oxedrine
  • bopindolol
  • orgotein (investigational)
  • oxaceprol
  • ormeloxifene
  • bevantolol
  • bifemelane
  • clebopride
  • demoxytocin
  • cicletanine
  • cefsulodin
  • chlortalidon
  • sisomicin
  • somatrem
  • carbazochrome
  • caroverine
  • cathine
  • ipriflavone
  • isepamicin
  • silymarin
  • simethicone
  • sermorelin
  • diloxanide
  • dimethindene
  • diosmin/hesperidin
  • calamine
  • canrenone
  • captodiame
  • imidapril
  • cefetamet
  • cefodizime
  • cefoperazone + sulbactam
  • ivermectin + albendazole
  • serrapeptase
  • bromisoval
  • beraprost
  • pridinol
  • proglumide
  • bamipine
  • barnidipine
  • bamifylline
  • benzbromarone
  • betamethasone/fusidic acid
  • para-chlorophenol
  • pantethine
  • nomifensine
  • pemoline
  • parnaparin
  • pentolinium
  • nialamide
  • novobiocin
  • nicergoline
  • octocrylene
  • octisalate
  • oftasceine
  • oxolamine
  • oxyphencyclimine
  • penfluridol
  • pentoxyverine
  • phenoxymethylpenicillin
  • picloxydine
  • pilsicainide hydrochloride
  • piperazine
  • pirarubicin
  • policresulen
  • prifinium bromide
  • prethcamide
  • pristinamycin
  • pirenzepine
  • piribedil
  • pimethixene
  • pargyline
  • phosphatidyl choline
  • phthalylsulfathiazole
  • phytomenadione
  • pranlukast
  • pinazepam
  • oxyphenonium
  • noxytiolin
  • periciazine
  • pethidine
  • phenindamine
  • histidine
  • isoleucine
  • proline
  • lauric acid
  • lymecycline
  • hypromellose
  • abiraterone acetate and niraparib
  • ichthammol
  • levamisole
  • naftazone
  • nefopam
  • oxprenolol
  • oxybuprocaine
  • elranatamab-bcmm
  • lapyrium
  • isoaminile
  • iotrolan
  • mazindol
  • masoprocol
  • lypressin
  • meradimate
  • molsidomine
  • monobenzone
  • mequinol/gluconolactone/ lactobionic acid/ arbutin
  • medifoxamine
  • mebutamate
  • metergoline
  • methantheline
  • methdilazine
  • metocurine
  • micronomicin
  • metaraminol
  • mephenesin
  • menadione
  • medrysone
  • metixene
  • levobetaxolol
  • guaiacol glycerol ether
  • eucalyptol
  • sodium tetradecyl sulfate
  • sugammadex
  • carbetocin
  • certoparin
  • chlorcyclizine/pseudoephedrine
  • cephapirin
  • indecainide
  • iobitridol
  • iomeprol
  • chlorphenesin
  • msud analog
  • msud maxamum
  • iceland moss
  • glutethimide
  • hexachlorophene
  • haloprogin
  • deferoxamine
  • ethchlorvynol
  • dexpanthenol topical
  • etilefrine
  • deslanoside
  • carbocromen
  • diazolidinylurea
  • dibenzepin
  • etofamide
  • guanoxan
  • halazepam
  • guanadrel sulfate
  • dapiprazole
  • soapwort
  • debrisoquine
  • l-tryptophan
  • chlormerodrin
  • chlorquinaldol
  • cetrimonium
  • carbocisteine
  • chlorcyclizine/codeine
  • technetium Tc-99m tetrofosmin
  • technetium Tc-99m disofenin
  • technetium Tc-99m gluceptate
  • technetium Tc-99m labeled red blood cells
  • amylmetacresol/dextromethorphan hydrobromide
  • anileridine phosphate
  • pyrethrins
  • pyrantel pamoate
  • quinagolide
  • spiramycin
  • standard hyperkalemic cardioplegia solution
  • technetium tc-99m mertiatide
  • technetium tc-99m medronate
  • bemotrizinol / bisoctrizole
  • benfotiamine
  • bemotrizinol + titanium dioxide + zinc oxide
  • technetium Tc-99m oxidronate
  • technetium Tc-99m pentetate
  • technetium Tc-99m pyrophosphate
  • benziodarone
  • octinoxate/bisoctrizole
  • bicisate dihydrochloride
  • technetium Tc-99m bicisate
  • norelgestromin/ethinyl estradiol
  • norgestimate/ethinyl estradiol
  • ximelagatran (investigational)
  • xamoterol
  • trioxsalen
  • poly-urea urethane
  • rilmenidine
  • pemirolast
  • oxitriptan
  • beclomethasone, intranasal
  • thimerosal
  • camphor gel
  • camphor
  • mumps virus vaccine, live
  • rubella virus vaccine, live
  • aluminum chloride (dental)
  • alum irrigation
  • framycetin, phenylephrine, and gramicidin
  • ombitasvir, paritaprevir, ritonavir, and dasabuvir
  • olipudase alfa
  • etonogestrel/ethinyl estradiol
  • mycophenolate
  • fluoroestradiol F 18
  • donor organ cardioplegia solution
  • fluciclovine F 18
  • fusidic acid (ophthalmic)
  • fusidic acid and hydrocortisone
  • framycetin, dexamethasone, and gramicidin
  • fludeoxyglucose F-18
  • fluorouracil/salicylic acid
  • indium In-111 oxyquinoline
  • indium In-111 pentetreotide
  • indium In-111 capromab pendetide
  • lusutrombopag
  • mitomycin (ophthalmic)
  • mifepristone and misoprostol
  • minoxidil (systemic)
  • methyl aminolevulinate (topical)
  • methyl folate, methylcobalamin, and acetylcysteine
  • ciclesonide/formoterol/tiotropium
  • nedocromil (Oral Inhalation)
  • batefenterol (Investigational)
  • neostigmine and glycopyrrolate
  • nepafenac ophthalmic
  • netupitant/palonosetron
  • meperidine and promethazine
  • mepivacaine and levonordefrin
  • maltodextrin
  • medical cannabis
  • medium chain triglycerides
  • mometasone/glycopyrrolate (glycopyrronium)/ indacaterol
  • moxifloxacin ophthalmic
  • neomycin/fluocinolone
  • nadroparin
  • iodine I-125 iothalamate
  • amikacin liposome (oral inhalation)
  • bupivacaine liposome
  • natamycin
  • lopinavir and ritonavir
  • lysine
  • macitentan and tadalafil
  • mitomycin pyelocalyceal
  • moclobemide
  • mometasone and indacaterol
  • efinaconazole
  • blue-green algae
  • indocyanine green
  • follitropin beta
  • lumasiran
  • glycerin/lidocaine
  • edrophonium/atropine
  • indigo carmine
  • lutropin alfa
  • instant glucose/intravenous dextrose
  • iobenguane I-123
  • ixekizumab
  • isosulfan blue dye
  • levofloxacin ophthalmic
  • levonorgestrel oral/ferrous bisglycinate/ ethinylestradiol
  • ethinyl estradiol/levonorgestrel transdermal
  • hydroquinone
  • hydroxypropyl methylcellulose
  • icodextrin
  • lipid emulsion (soybean, medium-chain triglyceride, olive, and fish oils; [SMOF])
  • iodinated I 125 albumin
  • iodinated I 131 albumin
  • lipid emulsion (plant oil-based)
  • levonorgestrel intrauterine
  • levonorgestrel/ethinyl estradiol
  • lactic acid and sodium-PCA
  • lactated Ringer solution
  • ketotifen (systemic)
  • lanolin
  • leuprolide and norethindrone
  • levodopa and benserazide
  • gonadorelin acetate
  • hemodialysis solutions
  • nirsevimab
  • gentian violet
  • gallium ga-68 dotatate
  • fusidic acid and betamethasone
  • gallium citrate Ga-67
  • gadopentetate dimeglumine
  • gadofosveset
  • follitropin delta
  • follitropin alfa and lutropin alfa
  • follitropin alfa
  • rocatinlimab
  • grass pollens allergen extract
  • flotufolastat F18
  • fluorescein ophthalmic
  • barium
  • balanced salt solution
  • air polymer type A intrauterine device
  • clodronate
  • bentoquatam
  • clobetasone
  • alfacalcidol
  • citric acid/glucono-delta-lactone/magnesium carbonate
  • benzoin
  • desirudin
  • immune globulin IV (IGIV)
  • dequalinium
  • pseudoephedrine/desloratadine
  • clofedanol
  • cyproterone and ethinyl estradiol
  • dextranomer and hyaluronic acid or derivatives
  • diatrizoate meglumine and diatrizoate sodium
  • glucosamine sulfate, chondroitin sulfate and Msm
  • squill
  • gotu kola
  • blessed thistle
  • bitter melon
  • apraclonidine
  • chlophedianol/dexbrompheniramine/pseudoephedrine
  • wild jujube
  • chitosan
  • cilazapril/hydrochlorothiazide
  • dexbrompheniramine and phenylephrine
  • diethylene triamine penta-acetic acid
  • dexchlorpheniramine and pseudoephedrine
  • lily of the valley
  • diflucortolone
  • corydalis
  • lemon balm
  • MSM
  • calcium polystyrene sulfonate
  • caprylidene
  • peppermint oil
  • efavirenz/lamivudine/tenofovir DF
  • emtricitabine/tenofovir DF /efavirenz
  • dutasteride/tamsulosin
  • milk thistle
  • centaury
  • horseweed
  • lycopus
  • agrimony
  • alfalfa
  • kava
  • cetrorelix
  • cetylpyridinium
  • chlophedianol and dexbrompheniramine
  • betahistine
  • choline C-11
  • boric acid vaginal suppository
  • aluminum acetate
  • aluminum chloride hexahydrate
  • 14-C urea breath test
  • absorbable collagen
  • valoctocogene roxaparvovec-rvox
  • amlodipine and celecoxib
  • aspirin and omeprazole
  • azilsartan and chlorthalidone
  • landiolol (Pending FDA approval)
  • isosorbide dinitrate/hydralazine
  • losartan/hydrochorothiazide
  • udenafil
  • dextromethorphan/quinidine
  • onasemnogene abeparvovec
  • orphenadrine/aspirin/caffeine
  • trace elements
  • sodium phenylbutyrate/ taurursodiol
  • fish oil triglycerides
  • infant formula
  • glutamine
  • chloroquine phosphate
  • afatinib
  • quinidine gluconate
  • methylergonovine
  • prothrombin complex concentrate, human
  • BCG intravesical live
  • capivasertib
  • cedazuridine
  • carbonyl iron
  • iron dextran complex
  • lovotibeglogene autotemcel (FDA Approval Pending)
  • sodium benzoate/sodium phenylacetate
  • mineral oil otic
  • zolmitriptan transdermal
  • midazolam intranasal
  • fosinopril/hydrochlorothiazide
  • caplacizumab
  • arginine
  • sodium phenylbutyrate
  • meloxicam/rizatriptan
  • manganese
  • acetaminophen/pamabrom/pyridoxine
  • varicella zoster immune globulin, human
  • amitriptyline/perphenazine
  • narsoplimab (Pending FDA Approval)
  • amlodipine/perindopril
  • imiglucerase
  • canagliflozin/metformin
  • tafamidis meglumine
  • somatrogon-ghla
  • glimepiride/rosiglitazone
  • becaplermin
  • lithium
  • loxapine inhaled
  • nicotine transdermal
  • tixagevimab and cilgavimab (Investigational)
  • muromonab CD3
  • ansuvimab
  • coal tar bath products
  • fibrin sealant
  • arimoclomol (FDA Approval Pending)
  • varenicline intranasal
  • aducanumab
  • oxycodone/naloxone
  • ritlecitinib
  • sodium polystyrene sulfonate
  • calcipotriene/betamethasone
  • calcium hydroxylapatite
  • cantharidin topical
  • doxepin cream
  • clocortolone
  • formaldehyde topical
  • sodium sulfide topical
  • collagenase
  • selegiline transdermal
  • foscarbidopa/foslevodopa (FDA approval pending)
  • saxagliptin/metformin
  • linagliptin/metformin
  • linzagolix (FDA approval pending)
  • efgartigimod/hyaluronidase SC
  • elamipretide (Pending FDA approval)
  • rozanolixizumab
  • diazoxide
  • glimepiride/pioglitazone
  • cipaglucosidase alfa
  • dihydroergotamine intranasal
  • delandistrogene moxeparvovec
  • beremagene geperpavec
  • hyaluronic acid and derivatives
  • hyaluronic acid, non-animal stabilized
  • eplontersen (FDA Approval Pending)
  • nitric oxide gas
  • sodium phenylbutyrate and taurursodiol
  • treprostinil SC
  • viltolarsen
  • albuterol/ipratropium
  • budesonide inhaled
  • budesonide rectal
  • palovarotene
  • sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol
  • amino acids mixture
  • aminobenzoate potassium
  • elivaldogene autotemcel
  • naproxen and sumatriptan
  • sumatriptan intranasal
  • alglucerase
  • metformin/rosiglitazone
  • ertugliflozin/metformin
  • elosulfase alfa
  • calcium carbonate/magnesium hydroxide
  • starch suppository
  • abicipar pegol (FDA Approval Pending)
  • riboflavin 5&#;-phosphate ophthalmic
  • povidone ophthalmic
  • glycerin oropharyngeal
  • dimethicone topical
  • menthol topical, dimethicone topical
  • pramoxine topical, menthol topical and dimethicone topical
  • phosphorated carbohydrate
  • brilliant blue G ophthalmic
  • brolucizumab intravitreal
  • purified water, ophthalmic
  • hydroxyethyl cellulose ophthalmic
  • ranibizumab intravitreal implant
  • sodium chloride hypertonic, ophthalmic&#;
  • cetirizine ophthalmic
  • phentolamine ophthalmic
  • ganciclovir ophthalmic
  • triamcinolone intravitreal
  • ocriplasmin intravitreal
  • atoltivimab/maftivimab/odesivimab
  • pegcetacoplan intravitreal
  • triamcinolone acetonide extended-release injectable suspension
  • tobramycin/loteprednol ophthalmic
  • 2-octyl cyanoacrylate
  • vitamins A & D topical
  • diphenhydramine/allantoin topical
  • pyrethrins/piperonyl butoxide
  • lodoxamide ophthalmic
  • obeticholic acid
  • fluocinolone intravitreal implant
  • sincalide
  • linaclotide
  • nedocromil ophthalmic
  • cysteamine ophthalmic
  • avacincaptad pegol intravitreal
  • azelastine ophthalmic
  • bacitracin ophthalmic
  • propylene glycol ophthalmic
  • rimexolone ophthalmic
  • metoclopramide intranasal
  • mirikizumab
  • netarsudil ophthalmic
  • cenegermin
  • dexamethasone ophthalmic insert
  • prednisolone ophthalmic
  • phenylephrine and cocoa butter rectal
  • phenylephrine and witch hazel topical
  • phenylephrine, pramoxine, glycerin and petrolatum rectal
  • bisacodyl rectal
  • aluminum hydroxide/magnesium carbonate
  • aluminum hydroxide/magnesium hydroxide
  • hyoscyamine spray
  • methenamine/methylene blue/ hyoscyamine/ sodium phosphate monobasic/ phenyl salicylate
  • phenylephrine
  • chlorophyll
  • castor oil
  • cholic acid
  • phenol oropharyngeal
  • articaine/epinephrine
  • antithymocyte globulin equine
  • aluminum hydroxide/magnesium trisilicate
  • methenamine/hyoscyamine
  • hydrocortisone topical/pramoxine topical 
  • sodium fluoride topical
  • mesna
  • C1 esterase inhibitor recombinant
  • menthol and pectin
  • menthol oropharyngeal
  • pectin oropharyngeal
  • gepirone
  • Goldenseal
  • polyethylene glycol and electrolytes
  • polyethylene glycol/electrolytes/sodium ascorbate/ascorbic acid
  • brompheniramine/pseudoephedrine/dextromethorphan
  • brompheniramine phenylephrine
  • acetaminophen/doxylamine/phenylephrine
  • doxylamine/acetaminophen/pseudoephedrine/dextromethorphan
  • acetaminophen/doxylamine/dextromethorphan
  • acetaminophen/doxylamine/dextromethorphan/phenylephrine
  • eslicarbazepine
  • fluticasone and salmeterol
  • codeine, acetaminophen, butalbital and caffeine
  • codeine, chlorpheniramine and phenylephrine
  • iodine
  • povidone iodine
  • butalbital/aspirin/caffeine/codeine
  • polyethylene glycol 400/propylene glycol ophthalmic&#;
  • pegvaliase
  • amivantamab
  • iopamidol
  • codeine and pseudoephedrine
  • emtricitabine, rilpivirine, tenofovir DF
  • penicillin G aqueous
  • miconazole topical
  • miconazole vaginal
  • ciprofloxacin inhaled (Pending FDA approval)
  • ceftazidime/avibactam
  • ceftolozane/&#;tazobactam
  • aztreonam inhalation
  • amphotericin B cholesteryl sulfate
  • miconazole oral
  • elvitegravir/cobicistat/emtricitabine/tenofovir DF
  • isavuconazonium sulfate
  • dapivirine intravaginal (FDA Approval Pending)
  • lamivudine/raltegravir
  • codeine/triprolidine/pseudoephedrine
  • cadexomer iodine
  • brompheniramine/pseudoephedrine
  • codeine/acetaminophen
  • codeine/guaifenesin
  • beclomethasone inhaled
  • epoetin beta/methoxy polyethylene glycol
  • voreloxin(Orphan Drug)
  • rociletinib
  • pitcher plant
  • phosphatidylserine
  • telotristat ethyl
  • copper CU 64 dotatate
  • urea topical
  • exenatide subdermal implant
  • asenapine transdermal
  • ethiodized oil
  • urea oral
  • miglustat
  • acalisib(Investigational)
  • acetophenazine
  • guggul
  • aceneuramic acid
  • mestranol/norethindrone
  • reishi
  • lactitol
  • vonoprazan fumarate
  • motherwort
  • silver nitrate
  • salicylic acid/sulfur shampoo
  • salicylic acid topical
  • ketorolac ophthalmic
  • ketoconazole topical
  • Japanese encephalitis virus vaccine
  • dibucaine topical ointment
  • ketorolac intranasal
  • ketorolac/phenylephrine ophthalmic
  • rotavirus oral vaccine, live
  • guarana
  • hops
  • krill oil
  • salicylic acid/coal tar shampoo
  • sufentanil SL
  • pancrelipase
  • passion flower
  • pepdite one plus
  • nivolumab and relatlimab
  • relatlimab (Pending FDA Approval)
  • benzalkonium chloride/benzocaine
  • ketotifen, drug-eluting contact lens
  • calcitriol topical
  • oxymetazoline topical
  • alclometasone topical
  • capsaicin topical
  • diclofenac/misoprostol
  • diclofenac ophthalmic
  • diclofenac topical
  • pramoxine/calamine topical
  • veverimer
  • tolazoline
  • olopatadine ophthalmic
  • lutetium lu 177-dota-tate
  • lutetium lu 177 vipivotide tetraxetan
  • strontium 89 chloride
  • interferon alfa n3
  • lutetium Lu 177- Diethylenetriamine Pentaacetic acid-omburtamab (FDA Approval Pending)
  • samarium sm 153 lexidronam
  • cytomegalovirus immune globulin (CMV IG)
  • antithymocyte globulin rabbit
  • inolimomab (Pending FDA Approval)
  • olopatadine intranasal
  • olopatadine intranasal/&#;mometasone, intranasal
  • benzocaine/butamben/tetracaine topical
  • antipyrine/benzocaine/phenylephrine
  • dyclonine/menthol
  • surufatinib
  • fruquintinib
  • dostarlimab
  • hepatitis B immune globulin (HBIG)
  • remestemcel-L
  • benzocaine/menthol oropharyngeal
  • interferon beta 1b
  • tetracaine/oxymetazoline intranasal
  • benzocaine oropharyngeal
  • benzalkonium chloride/menthol/petrolatum topical
  • inamrinone
  • alpha 1 proteinase inhibitor
  • potassium bicarbonate/potassium citrate
  • potassium phosphate/sodium acid phosphate
  • asparaginase Erwinia chrysanthemi recombinant
  • motixafortide
  • pegloticase
  • etesevimab
  • Rho(D) immune globulin
  • tetanus immune globulin (TIG)
  • reltecimod (pending FDA approval)
  • avasopasem
  • trimethoprim/polymyxin B ophthalmic
  • naphazoline ophthalmic
  • sulfacetamide topical
  • sirolimus intravitreal (pending FDA approval)
  • sirolimus protein bound
  • sirolimus topical
  • glycopyrronium tosylate topical
  • sofpironium
  • olmesartan, amlodipine and hydrochlorothiazide
  • dovitinib (Pending FDA Approval)
  • epinephrine inhaled
  • quizartinib (Pending FDA Approval)
  • ranibizumab intravitreal injection
  • sodium hyaluronate
  • bacitracin and lidocaine topical
  • brimonidine topical
  • benzoyl peroxide and tretinoin topical
  • talquetamab
  • betrixaban
  • acetaminophen/caffeine/pyrilamine
  • fentanyl transmucosal
  • bacitracin topical
  • buprenorphine,long-acting injection
  • buprenorphine buccal
  • nalmefene intranasal
  • sulbactam/durlobactam
  • metronidazole topical&#;
  • daratumumab/hyaluronidase
  • glofitamab
  • rituximab-hyaluronidase
  • drospirenone/ethinyl estradiol/levomefolate
  • loncastuximab tesirine
  • ingenol mebutate topical
  • momelotinib
  • trastuzumab/deruxtecan
  • trastuzumab/hyaluronidase
  • trastuzumab duocarmazine
  • lifileucel
  • umbralisib
  • eflornithine/sulindac
  • cytarabine/daunorubicin liposomal
  • doxorubicin liposomal
  • epcoritamab
  • lanadelumab&#;&#;
  • esomeprazole/naproxen&#;
  • terbinafine topical
  • ravulizumab
  • clotrimazole topical
  • choline magnesium trisalicylate
  • tacrolimus ointment
  • mechlorethamine topical
  • donislecel
  • pozelimab (Pending FDA Approval)
  • human rabies immune globulin (HRIG)
  • melphalan flufenamide
  • sintilimab (Pending FDA Approval)
  • oportuzumab monatox (Pending FDA Approval)
  • sotorasib
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attapulgite + 

No drug interaction found for attapulgite and .


Suggested dosing 

Liquid 

750mg/15mL 

Tablet 

600mg 

Diarrhea 


Diarrhea
1.2-1.5 gm orally after the loose bowel movement.
Should not exceed 8.4 gm in a day




Suggested dosing 

Liquid 

750mg/15mL 

Tablet 

600mg 

Diarrhea 


Diarrhea
Age 6-12 years
600-750 mg orally after the loose bowel movement.
Should not exceed 4.5 gm in a day
Age 3-6 years
300 mg orally after the loose bowel movement.
Should not exceed 2.1 gm in a day




Refer to adult dosing 

Frequency not defined 

Gas (flatulence) 

Indigestion 

Bloating 

Nausea 

Heartburn 

Mild constipation 

Black Box Warning: 

Because of intestinal obstruction or impaction risk, attapulgite carries a black box warning from the US Food and Drug Administration (FDA). A black box warning is the severe type of warning the FDA can require for a medication or supplement. It is intended to alert healthcare providers and patients to the potential for severe or life-threatening side effects. 

The black box warning for attapulgite advises that it should be used cautiously and only under medical supervision, especially in people with a history of bowel obstruction or impaction or in those who are elderly or debilitated.

It also recommends that attapulgite should not be used for more than one week without medical supervision and should be taken with plenty of water to help prevent intestinal blockage. If you experience any symptoms of intestinal obstruction or impaction while taking attapulgite, you should seek immediate medical attention. 

Contraindication/Caution: 

Contraindication 

attapulgite is considered safe when used in recommended doses and under medical supervision. However, like any medication or supplement, attapulgite may not be suitable for everyone and may have contraindications. 

attapulgite should not be used in people who are hypersensitive or allergic to its components. Additionally, attapulgite may not be suitable for people with certain medical conditions, including: 

  • Intestinal obstruction or impaction

     

  • Severe constipation

     

  • Preexisting kidney disease or kidney failure

     

  • Dehydration or fluid loss

     

  • Difficulty swallowing

     

  • Pregnancy and breastfeeding.

     

attapulgite is not recommended for use in children under the age of six. 

It is essential to consult with a healthcare provider before using attapulgite or any other medication or supplement, especially if you have any underlying medical conditions or are taking other medications. Your healthcare provider can help determine whether attapulgite is appropriate for you based on your health history and current medications. 

Caution 

While attapulgite is generally considered safe when used in recommended doses and under medical supervision, there are some cautions to keep in mind. 

  • Dehydration: attapulgite can cause dehydration if not taken with enough water or used for prolonged periods. This can be especially concerning in elderly individuals, young children, and people with preexisting kidney disease or kidney failure.

     

  • Interactions with other medications: attapulgite can interfere with the absorption of certain medications, including antibiotics, anticoagulants, and vitamins and minerals. Talking to your healthcare provider before using attapulgite with any other medication or supplement is essential.

     

  • Delayed diagnosis: attapulgite can mask the symptoms of underlying medical conditions, such as inflammatory bowel disease, colon cancer, or infections. It is key to seek medical attention if your symptoms do not improve or worsen after using the attapulgite.

     

  • Overuse: attapulgite should not be used for more than one week without medical supervision, as prolonged use can lead to intestinal obstruction or impaction.

     

    Are you interested in learning more about Attapulgite Benefits? Contact us today to secure an expert consultation!

  • Allergic reactions: Although rare, some people may develop an allergic reaction to attapulgite. If you experience rash, itching, swelling, or difficulty breathing, seek medical attention immediately.

     

Pregnancy consideration:  

Pregnancy Category: N/A 

Lactation: N/A 

Pregnancy category: 

  • Category A:

    well-controlled and Satisfactory studies do not show risk to the fetus in the first/later trimester.

    &#;&#;&#;&#;&#;&#;

    &#;

     

  • Category B:

    there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women&#;&#;&#;&#;&#;&#;

    &#;

     

  • Category C:

    there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.&#;&#;&#;&#;

    &#;

    &#;

     

  • Category D:

    adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.&#;&#;&#;&#;&#;

    &#;

    &#;

     

  • Category X:

    Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.

    &#;

    &#;

     

  • Category N:

    There is no data available for the drug under this category

     

Pharmacology: 

attapulgite is a naturally occurring clay-like substance composed of magnesium aluminum silicate. When ingested, it acts as an absorbent agent in the gastrointestinal tract, binding to water, toxins, and other substances and forming a protective coating on the intestinal lining. 

attapulgite has no systemic absorption, meaning it stays in the gastrointestinal tract and does not enter the bloodstream. This makes it a relatively safe medication with few side effects. 

The primary pharmacological actions of attapulgite are: 

  • Absorption of water: attapulgite absorbs excess water in the gastrointestinal tract, which can help reduce the frequency and severity of diarrhea and relieve symptoms of IBS.

     

  • Absorption of toxins: attapulgite can bind to toxins and other harmful substances in the gastrointestinal tract, preventing their absorption into the bloodstream and reducing the severity of poisoning or overdose symptoms.

     

  • Protection of the gastrointestinal lining: attapulgite forms a protective coating on the intestinal and stomach lining, which can help reduce inflammation and irritation caused by excess acid or other irritants.

     

Pharmacodynamics: 

Mechanism of action: The action of attapulgite is based on its ability to adsorb water and other substances in the gastrointestinal tract. attapulgite is a naturally occurring clay-like substance that contains magnesium aluminum silicate. 

When ingested, attapulgite forms a gel-like substance that binds to water, toxins, and other substances in the intestines. This can help reduce diarrhea&#;s volume and frequency by absorbing excess water and increasing stool consistency. 

attapulgite also forms a protective coating on the intestinal lining, which can help to reduce inflammation and irritation caused by excess acid or other irritants. This protective coating can help to relieve symptoms of indigestion, heartburn, and irritable bowel syndrome (IBS). 

Pharmacokinetics: 

Absorption 

attapulgite is not absorbed systemically, meaning it stays within the gastrointestinal tract and does not enter the bloodstream. 

Distribution 

It works locally in the gut and does not distribute to other body parts. 

Metabolism 

Due to its large particle size and insolubility, attapulgite is not metabolized by the body. Instead, it passes through the gastrointestinal tract unchanged. 

Elimination and Excretion 

attapulgite is primarily excreted in the feces. The unabsorbed particles of attapulgite combine with water and waste materials in the gastrointestinal tract and are eliminated from the body in the stool. Some small amounts of attapulgite may be excreted in the urine, but this is not a significant route of elimination. 

Administration: 

Oral administration 

attapulgite is typically available in the form of an oral suspension or tablet. It is essential to follow the instructions on the label or those provided by a healthcare provider for the specific product. 

Here are some general guidelines for administering attapulgite: 

  • Shake the bottle or package well before using it to ensure the attapulgite is evenly distributed.

     

  • Take attapulgite with plenty of water to help prevent intestinal obstruction or impaction.

     

  • Do not crush, chew, or break attapulgite tablets. Swallow them whole with water.

     

  • Do not take attapulgite at the same time as other medications or supplements, as it can interfere with their absorption. Allow at least two hours between taking an attapulgite and any other medication or supplement.

     

  • Do not exceed the recommended dose or duration of use, as prolonged use can lead to intestinal obstruction or impaction.

     

Patient information leaflet 

Generic Name: attapulgite 

Why do we use attapulgite? 

attapulgite is a medication that is used for the treatment of several conditions, including: 

  • Diarrhea: attapulgite can treat diarrhea by absorbing excess water in the intestines and forming a protective coating on the intestinal lining. This can help reduce the frequency and severity of diarrhea.

     

  • Indigestion: attapulgite can relieve indigestion symptoms, such as bloating, nausea, and abdominal discomfort. It absorbs excess stomach acid and forms a protective coating on the stomach lining.

     

  • Heartburn: attapulgite can also treat heartburn, a burning sensation in the chest caused by stomach acid reflux. It absorbs excess stomach acid and forms a protective coating on the esophagus.

     

  • Poisoning: attapulgite can treat poisoning or overdose by binding to the toxic substance in the gastrointestinal tract and preventing its absorption into the bloodstream. This can help reduce the severity of poisoning symptoms.

     

  • Irritable bowel syndrome (IBS): attapulgite can relieve symptoms of IBS, such as abdominal pain, bloating, and diarrhea. It absorbs excess water in the intestines and forms a protective coating on the intestinal lining.

     

Talking to a healthcare provider before using attapulgite is essential, especially if you have any underlying medical conditions or are taking other medications. They can guide the appropriate use of attapulgite based on your health history and needs. 

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